Reversal of cognitive decline: A novel therapeutic program
Action Against Alzheimer’s (AAA) is a self-help diet and lifestyle programme to optimise cognitive health using techniques that have been shown in research to reverse symptoms of cognitive decline. AAA is based on the work of Professor Bredesen who works at the Buck Institute in the US.
Cytoplan helps to bring his work surrounding Alzheimer’s to the UK.
The Bredesen Protocol™, is a multi-factorial lifestyle and nutrition based approach to treating, and reversing, early onset Alzheimer’s,. It has so far successfully reversed Alzheimer’s symptoms in 90% of 110 people.
I am available for:
- Public talks to raise awareness,
- Workshops to learn what kind of approaches work and how to implement them in daily life
- Private consultations to treat individual patients
Reversal of cognitive decline: A novel therapeutic program Dale E. Bredesen
This report describes a novel, comprehensive, and personalized therapeutic program that is based on the underlying pathogenesis of Alzheimer’s disease, and which involves multiple modalities designed to achieve metabolic enhancement for neurodegeneration (MEND). The first 10 patients who have utilized this program include patients with memory loss associated with Alzheimer’s disease (AD), amnestic mild cognitive impairment (aMCI), or subjective cognitive impairment (SCI). Nine of the 10 displayed subjective or objective improvement in cognition beginning within 3‐6 months, with the one failure being a patient with very late stage AD. Six of the patients had had to discontinue working or were struggling with their jobs at the time of presentation, and all were able to return to work or continue working with improved performance. Improvements have been sustained, and at this time the longest patient follow‐up is two and one‐half years from initial treatment, with sustained and marked improvement. These results suggest that a larger, more extensive trial of this therapeutic program is warranted. The results also suggest that, at least early in the course, cognitive decline may be driven in large part by metabolic processes. Furthermore, given the failure of monotherapeutics in AD to date, the results raise the possibility that such a therapeutic system may be useful as a platform on which drugs that would fail as monotherapeutics may succeed as key components of a therapeutic system.
Bredesen Protocol: Next Generation Protocol developed by the Inventors of MEND
AMPK links cognitive decline reversal in Alzheimer’s disease with Progeria, HIV-1 latency, & Oocyte activation: The "Shock and Live" approach
AMKP explained here.
Glucose deprivation, fasting, caloric restriction, and exercise all induce varying levels of “shock” (mediated by increased levels of ROS, intracellular Ca2+, or AMP/ATP ratio), leading to the activation of AMPK and AMPK-induced autophagy (“live”). Several naturally-occurring compounds, including EPA, DHA, melatonin, folic acid, selenium, alpha-lipoic acid, and acetyl-l-carnitine also activate AMPK, likely via the induction of a cellular stress response. Additionally, brain stimulation via electrical pulses also leads to the activation of AMPK (and long-term potentiation—a process that underlies learning and memory), similar to oocyte activation induced by electrical stimulation.
Components of the MEND Protocol that activate AMPK with references:
- Glucose deprivation/low glycemic diet activates AMPK [1,2].
- Fasting and caloric restriction activates AMPK. AMPK stimulates brain ketogenesis and authophagy [3-6].
- AMPK reduces cortiol levels .
- Melatonin activates AMPK .
- Aerobic exercise activates AMPK .
- Brain stimulation via high frequency stimulation (HFS) activates AMPK .
- MTHF (Folic acid) activates AMPK .
- EPA, DHA, and curcumin activate AMPK [12-14].
- fT3, E2, and T activate AMPK [15-17].
- Prebiotics and probiotics activate AMPK [18,19].
- Curcumin activates AMPK. Ashwagandha likely activates AMPK [12,20].
- MgT likely activates AMPK .
- Vitamin D3 activates AMPK .
- ALCAR activates AMPK .
- Tocotrienols, Se, blueberries, and α-lipoic acid activate AMPK [24-27].
- CoQ10, α-lipoic acid, ALCAR, Se, and resvertrol activate AMPK. PQQ likely activates AMPK [23,25-30].
- Resveratrol activates AMPK [26,29].
- MCT/Coconut oil likely activates AMPK 
Dale E. Bredesen 1, 2
- 1 Mary S. Easton Center for Alzheimer's Disease Research, Department of Neurology, University of California, Los Angeles, CA 90095;
- 2 Buck Institute for Research on Aging, Novato, CA 94945